What are the three major crises of sickle cell disease?
Four major types of crises are recognised in sickle cell anaemia: aplastic, acute sequestration, hyper-haemolytic, and vaso-occlusive crises.
What is the most common complication of sickle cell disease?
Pain “Episode” or “Crisis” Pain is the most common complication of SCD, and the number 1 reason that people with SCD go to the emergency room or hospital. When sickle cells travel through small blood vessels, they can get stuck and clog the blood flow.
What causes acquired hemophilia A?
Acquired hemophilia A is a disorder of rare entity, resulting in spontaneous bleeding in individuals with no history of bleeding disorders. It is believed to be caused by spontaneous inhibition of clotting factor VIII by autoantibodies, and is usually associated with other autoimmune conditions.
Is hemophilia A an autoimmune disease?
Acquired hemophilia (AH) is a rare autoimmune disorder characterized by bleeding that occurs in patients with no personal or family history of diseases related to clotting/coagulation. Autoimmune disorders occur when the body’s immune system mistakenly attacks healthy cells or tissue.
What blood type carries sickle cell?
Like most genes, individuals inherit one from each parent. Examples: If one parent has sickle cell anemia (SS) and the other parent has normal (AA) blood, all of the children will have sickle cell trait.
What are five symptoms of a sickle cell crisis?
Signs and symptoms can include:
- Anemia. Sickle cells break apart easily and die.
- Episodes of pain. Periodic episodes of extreme pain, called pain crises, are a major symptom of sickle cell anemia.
- Swelling of hands and feet.
- Frequent infections.
- Delayed growth or puberty.
- Vision problems.
What should sickle cell patients avoid?
avoid very strenuous exercise – people with sickle cell disease should be active, but intense activities that cause you to become seriously out of breath are best avoided. avoid alcohol and smoking – alcohol can cause you to become dehydrated and smoking can trigger a serious lung condition called acute chest syndrome.
What is the average life expectancy of a person with hemophilia?
Estimated median life expectancy of patients with hemophilia was 77 years, 6 years lower than the median life expectancy of the general Dutch male population (83 years).
What foods to avoid if you have hemophilia?
Food and supplements to avoid
- large glasses of juice.
- soft drinks, energy drinks, and sweetened tea.
- heavy gravies and sauces.
- butter, shortening, or lard.
- full-fat dairy products.
- candy.
- foods containing trans fats, including fried. foods and baked goods (pastries, pizza, pie, cookies, and crackers)
Which is worse hemophilia A or B?
Recent evidence suggests that hemophilia B is clinically less severe than hemophilia A, highlighting the need to discuss further therapeutic options for each type of hemophilia. The study, “Haemophilia B is clinically less severe than haemophilia A: further evidence,” was published in Blood Transfusion.
What is B blood type?
Group B: The surface of the red blood cells contains B antigen, and the plasma has anti-A antibody. Anti-A antibody would attack blood cells that contain A antigen. Group AB: The red blood cells have both A and B antigens, but the plasma does not contain anti-A or anti-B antibodies.
What is von Willebrand disease (vWD)?
Although referred to as a single disease, von Willebrand disease (VWD) is in fact a family of bleeding disorders caused by an abnormality of the von Willebrand factor (VWF). von Willebrand disease is the most common hereditary bleeding disorder. [ 1, 2]
Does von Willebrand disease require an emergency appendectomy?
An emergency appendectomy was performed in a patient with von Willebrand disease (vWD) and asthma. vWD is a hemostatic disorder in which the patient lacks von Willebrand factor, playing a critical role in the mediation of platelet adhesion. A 12-year-old boy with vWD underwent an appendectomy under general anesthesia.
What are the contraindications for von Willebrand disease?
Type 2 von Willebrand disease. DDAVP trials may be contraindicated in patients with type 2B, because of thrombocytopenia and possible thrombotic complications. DDAVP is usually not effective in patients with type 2M and is rarely effective in patients with type 2N.
What is the prognosis of von Willebrand disease during pregnancy?
vWF in pregnancy. During pregnancy, the vWF level increases in most patients with non–type 3 vWD. Thus, in patients with functionally normal vWF, labor and delivery usually proceed normally. However, patients with type 2 disease may experience hemorrhagic problems.
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