How serious is HSIL?
High-Grade Squamous Intraepithelial Lesions (HSIL) means that there are moderately or severely abnormal cervical cells that could become cancer in the future if not treated.
Can you have HSIL and cancer?
HSILs are associated with persistent infection and a greater risk of progression to invasive cancer, especially if the persistent infection is a high-risk genotype such as HPV16 and/or HPV 18.
What does HSIL mean?
HSIL ~ High-grade squamous intraepithelial lesion This diagnosis means the cells appear very different from normal cells. These precancerous lesions are more severe than with LSIL, but involve cells on the surface of the cervix. They may also be called moderate or severe dysplasia, or CIN 2 or 3.
How fast does HSIL develop?
high-grade squamous intraepithelial lesions (HSIL) In about 10 percent of cases, LSIL progresses to high-grade squamous intraepithelial lesions (HSIL) within two years.
Does AGC mean cancer?
A finding of abnormal cells in a Pap test. The glandular cells come from the inner part of the cervix or the lining of the uterus. This finding may be a sign of cancer or other serious condition, and more testing may be needed.
What causes ASCUS?
ASCUS may be caused by a vaginal infection or an infection with a virus called HPV (human papillomavirus, or wart virus). Your doctor will talk with you about the options of looking at your cervix with a microscope (colposcopy) or repeating your Pap smear every six months for two years.
What causes LSIL?
Cause. LSIL is almost always caused by human papillomavirus (HPV), the primary risk factor for cervical cancer. 2 HPV is easily transmitted through vaginal, anal, or oral sex. The good news is that the majority of people infected with HPV clear the virus spontaneously.
Can you have HSIL without HPV?
Less commonly, non-hrHPV genotypes were associated with 29% of HSIL or worse lesions in the cohort, primarily with a single genotype infection. No detectable HPV was found in 1 of the biopsy samples after analysis using all 3 HPV assays.
How do I clear my HSIL?
Excisional treatments for HSIL include:
- Loop Electrosurgical Excision Procedure (LEEP): During a LEEP, an electric current is sent through a wire loop.
- Conization: Also called a cone biopsy or cold knife ionization, conization removes a larger, cone-shaped sample of abnormal tissue.
What is adenocarcinoma with histopathologic characteristics (AGC)?
AGC is the term used to categorize glandular cells with cytologic features that are too pronounced to be called inflammatory or reactive but cannot be classified as malignant (endocervical adenocarcinoma in situ or invasive).
What percentage of AGC-Nos lesions are precancerous or cancerous?
56.3% of all histologically verified AGC-NOS diagnoses were associated with a precancerous and/or cancerous lesion. Excluding the 3 metastatic AC, we found 44% (44/100) of the precancerous or cancerous lesions with an endocervical origin and 56% (56/100) with an endometrial origin.
How common is an AGC diagnosis’not otherwise specified’?
An AGC diagnosis ‘not otherwise specified’ was made in 261 cases corresponding to 0.05% of all cervical Pap-smears. 24 patients (9.2%) were lost to follow-up and 46 patients (17.6%) had repeat cytology only. 70 AGC patients (26.8%) had no histological follow-up data.
What is the prognosis of atypical glandular cells (AGC)?
Atypical glandular cells (AGC) diagnosis should be immediately followed up with a clinician. There is risk of premalignant lesions in patients diagnosed with AGC is as high as 11%, the risk of endometrial cancer is 3%, and the risk of cervical cancer is 1%. AGC is found in <1% of cervical cytology specimens.